• br Introduction Protein modification by ubiquitin and ubiqui

  2019-09-16

  

  Introduction Protein modification by ubiquitin and ubiquitin-like proteins is one of the most common and important regulatory mechanisms in biology (Finley et al., 2004, Pickart, 2004). Ubiquitination is carried out by an enzymatic cascade consisting of three steps. In the first step, ubiquitin i

• In addition to glutamatergic inputs the RTn integrates choli

  2019-09-16

  

  In addition to glutamatergic inputs, the RTn integrates cholinergic, serotonergic and noradrenergic synapses of fibers coming from nuclei located in the brainstem (Asanuma, 1992, Morrison and Foote, 1986, Pare et al., 1988) involved in the alternating firing mode and in the frequency changes of reti

• Does a universal mechanism for

  2019-09-16

  

  Does a universal mechanism for TLS exist? Our previous studies using the bacteriophage T4 DNA polymerase generated the model provided in Fig. 7 that quantifies the molecular forces influencing key steps in the polymerization pathway during the replication of a non-instructional versus miscoding DNA

• br Contributors br Acknowledgements br Introduction Pemphigu

  2019-09-16

  

  Contributors Acknowledgements Introduction Pemphigus disorders are characterized by autoantibodies binding to desmosomes between epidermal cells, resulting in the loss of cell to cell adhesion and blister formation. In pemphigus foliaceus, autoantibodies predominantly bind to desmoglein 1,

• For immobilization of enzymes natural polymers depict severa

  2019-09-12

  For immobilization of enzymes, natural polymers depict several outstanding features as support. These materials are inert, non-toxic, biodegradable and biocompatible.

• Another interesting study was that by Kotyuk et al who

  2019-09-11

  Another interesting study was that by Kotyuk et al. (2015), who investigated the association between COMT rs4680 and personality in elderly people. The authors analysed the association between COMT rs4680 and NEO-FFI.

• While we previously demonstrated that TraG is

  2019-09-10

  While we previously demonstrated that TraG is inhibited by specific transglycosylase inhibitors and that enzymatic activity is strongly reduced upon mutation of the potential catalytic core (Arends et al., 2013), the enzymatic mechanism of both domains was not assigned.

• Conclusion br Introduction The morphological variability of

  2019-09-09

  Acknowledgements This work was supported by the European Committee Fifth Framework Project QLK5-1999-01360.

• In the course of this

  2019-09-07

  In the course of this study, K+PFOS did not appear to have any effect on the thyroid parameters evaluated (H&E histology, follicular epithelial cell proliferation, and follicular epithelial apoptosis).

• In general accurate results for the

  2019-09-06

  In general, accurate results for the prediction of the solubility in scCO2 + cosolvents using the CPA-EoS were verified.

• From these and other studies it is clear that acriflavine

  2019-09-05

  From these and other studies, it is clear that acriflavine is an interesting DB07268 with pleiotropic anticancer effects [21], [22], [43].

• Conflict of interest statement Acknowledgements Introducti

  2019-09-04

  Conflict of interest statement Acknowledgements Introduction Spending their last days on earth having already lost many cognitive functions remains a major fear of elderly people.

• Our finding that the ATRX DAXX H complex promotes a

  2019-09-03

  Our finding that the ATRX-DAXX-H3.3 complex promotes a form of HR is likely to have important implications for our understanding of the ALT recombination process that takes place at telomeres. We were surprised to observe that ATRX promotes a form of HR, since loss of the ATRX-DAXX-H3.3 complex is necessary for generating the ALT phenotype (Lovejoy et al., 2012).

• In summary the loss of seven Cyp a genes lead

  2019-09-02

  In summary, the loss of seven Cyp3a genes lead to sexual dimorphic changes during the eight weeks of high fat diet treatment with Cyp3a-null female mice showing a healthier acclimation to a high fat diet through decreased weight gain, higher adiponectin, lower B-OHB levels, and a better response to glucose; while the Cyp3a-null males succumb to increased fatty liver including slightly increased weight, higher hepatic polar lipids and triglycerides, and greater liver weight. Overall, the changes in HFD-induced health parameters in females are consistent with other studies showing that compounds that inhibit Cyp3a or perturb Cyp3a-mediated fatty c-FMS inhibitor metabolism protect from obesity [74,93], and the increases in weight in males are moderate.

• Results and discussion A systematic search for genes

  2019-08-30

  Results and discussion A systematic search for genes encoding H+-PPases was carried out by PCR using genomic DNA from a wide range of protozoa as templates and degenerate oligonucleotides, designed from amino Capsaicin domains conserved in H+-PPases of higher plants and the proteobacterium R. rubrum, as primers.

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