• Given the excellent in vitro

  2019-09-17

  

  Given the excellent in vitro pharmacology profiles of methyl ester 28 and primary amide 29 efforts were reengaged on neutral analogs of these leads, with a focus on non-amide replacements for the carboxylic papain inhibitor functionality of 1. Acetonitrile 49 was found to have a good balance of DGAT

• Introduction With an annual world production

  2019-09-16

  

  Introduction With an annual world production of around 750 million tons, wheat is grown on more agricultural area than any other food crop and is the main source of plant protein in human nutrition [1,2]. Wheat is composed of 8–15% protein, from which 85–90% is gluten [3]. The unique viscoelastic a

• br Introduction Protein modification by ubiquitin and ubiqui

  2019-09-16

  

  Introduction Protein modification by ubiquitin and ubiquitin-like proteins is one of the most common and important regulatory mechanisms in biology (Finley et al., 2004, Pickart, 2004). Ubiquitination is carried out by an enzymatic cascade consisting of three steps. In the first step, ubiquitin i

• In addition to glutamatergic inputs the RTn integrates choli

  2019-09-16

  

  In addition to glutamatergic inputs, the RTn integrates cholinergic, serotonergic and noradrenergic synapses of fibers coming from nuclei located in the brainstem (Asanuma, 1992, Morrison and Foote, 1986, Pare et al., 1988) involved in the alternating firing mode and in the frequency changes of reti

• Does a universal mechanism for

  2019-09-16

  

  Does a universal mechanism for TLS exist? Our previous studies using the bacteriophage T4 DNA polymerase generated the model provided in Fig. 7 that quantifies the molecular forces influencing key steps in the polymerization pathway during the replication of a non-instructional versus miscoding DNA

• br Contributors br Acknowledgements br Introduction Pemphigu

  2019-09-16

  

  Contributors Acknowledgements Introduction Pemphigus disorders are characterized by autoantibodies binding to desmosomes between epidermal cells, resulting in the loss of cell to cell adhesion and blister formation. In pemphigus foliaceus, autoantibodies predominantly bind to desmoglein 1,

• For immobilization of enzymes natural polymers depict severa

  2019-09-12

  For immobilization of enzymes, natural polymers depict several outstanding features as support. These materials are inert, non-toxic, biodegradable and biocompatible.

• Another interesting study was that by Kotyuk et al who

  2019-09-11

  Another interesting study was that by Kotyuk et al. (2015), who investigated the association between COMT rs4680 and personality in elderly people. The authors analysed the association between COMT rs4680 and NEO-FFI.

• While we previously demonstrated that TraG is

  2019-09-10

  While we previously demonstrated that TraG is inhibited by specific transglycosylase inhibitors and that enzymatic activity is strongly reduced upon mutation of the potential catalytic core (Arends et al., 2013), the enzymatic mechanism of both domains was not assigned.

• Conclusion br Introduction The morphological variability of

  2019-09-09

  Acknowledgements This work was supported by the European Committee Fifth Framework Project QLK5-1999-01360.

• In the course of this

  2019-09-07

  In the course of this study, K+PFOS did not appear to have any effect on the thyroid parameters evaluated (H&E histology, follicular epithelial cell proliferation, and follicular epithelial apoptosis).

• In general accurate results for the

  2019-09-06

  In general, accurate results for the prediction of the solubility in scCO2 + cosolvents using the CPA-EoS were verified.

• From these and other studies it is clear that acriflavine

  2019-09-05

  From these and other studies, it is clear that acriflavine is an interesting DB07268 with pleiotropic anticancer effects [21], [22], [43].

• Conflict of interest statement Acknowledgements Introducti

  2019-09-04

  Conflict of interest statement Acknowledgements Introduction Spending their last days on earth having already lost many cognitive functions remains a major fear of elderly people.

• Our finding that the ATRX DAXX H complex promotes a

  2019-09-03

  Our finding that the ATRX-DAXX-H3.3 complex promotes a form of HR is likely to have important implications for our understanding of the ALT recombination process that takes place at telomeres. We were surprised to observe that ATRX promotes a form of HR, since loss of the ATRX-DAXX-H3.3 complex is necessary for generating the ALT phenotype (Lovejoy et al., 2012).

13863 records 923/925 page Previous Next First page 上5页 921922923924925