• Abnormal expression and higher activity of GLO I have been

  2022-06-28

  

  Abnormal expression and higher activity of GLO I have been detected more in various tumor eht library than in normal cell samples., , , , , , , Among cancer cell lines, lung carcinoma cells frequently showed higher GLO1 activity. Human NSCLC cell line NCI-H522 cells possess high activity and expre

• Long non coding RNAs lncRNAs are mRNA

  2022-06-28

  

  Long non-coding RNAs (lncRNAs) are mRNA-like transcripts of greater than 200 nucleotides (nt), with little or no protein-coding potential [13,14]. LncRNAs have been suggested to participate in transcription and post-transcription regulation as scaffolds, guides, decoys or repressors, activators, and

• br Materials and methods br Results br

  2022-06-27

  

  Materials and methods Results Discussion Importantly, we observed that treatment with DA3-CH could reduce the pathophysiological processes in the hippocampal CA1 area after SE. At present, the unimolecular dual incretin receptor agonist has been developed as a treatment for type 2 diabetes,

• Due to the versatility of

  2022-06-27

  

  Due to the versatility of the ghrelin system and its multiple functions, dysregulation in some of the components of the ghrelin system, such as ghrelin, GOAT, and GHSR, might lead to pathogenesis of many endocrine-related diseases, including obesity, short stature, cancer, inflammatory, and cardiova

• To date types of glucose

  2022-06-27

  

  To date, 14 types of glucose transport protein have been discovered, each having its own specific functions with different distributions [33]. Among these, GLUT4 is particularly important for maintaining glucose metabolism homeostasis and insulin sensitivity, since it is involved in glucose transpor

• The overall very satisfactory potency

  2022-06-27

  

  The overall very satisfactory potency profile of compounds 7a–l suggests that 1,3,4-thiadiazole-2-carboxamide moiety was a suitable periphery group to add to the 3-phenylpropanoic Cisatracurium Besylate mg core in order to improve affinity to FFA1. The agonist activity in this series appears to be

• br Results and discussion Computer

  2022-06-27

  

  Results and discussion Computer modelling studies suggested that the endocyclic oxygens in furocoumarin derivatives, such as BCTC 3a (Fig. 1), could also coordinate metal ions in the HIV-1 IN enzyme active site and inhibit the integration of viral DNA. The coumarin moiety is found in various medi

• Pharmacological G a inhibition resulted in significant

  2022-06-27

  

  Pharmacological G9a inhibition resulted in significant reduction of viable BTC cells in a concentration- and cell line–dependent manner. Interestingly, we found a significant correlation between BIX01294-IC50 and UNC0642-IC50 values in our BTC cell model—both inhibitors competitively inhibit H3K9 su

• br To explore further the functional impact

  2022-06-27

  

  To explore further the functional impact of the similarity of the UTY and KDM6A proteins, the FANTOM5 human dataset was analysed to determine whether or not the genes were expressed at the same time in the same tissues (which would suggest that they are controlled by the same regulators) or with o

• LY 2389575 hydrochloride We notice that previous reports of

  2022-06-27

  

  We notice that previous reports of arsenic exposure are not completely consistent with each other, in terms of exposure-changed histone acetylations. In an early investigation, As exposure (7.5 μM) of HepG2 LY 2389575 hydrochloride increased H3K9ac after 24 h, when analyzed by methods of immunofluo

• SCH527123 br Acknowledgements This research was

  2022-06-27

  

  Acknowledgements This research was supported by the Natural Sciences and Engineering Council of Canada (NSERC) Discovery Grant awarded to RGM. LMW was supported in part by fellowships from the University of Regina and the Government of Saskatchewan Fish and Wildlife Development Fund (FWDF). We wo

• FOLE was recently approved for use in PN dependent

  2022-06-27

  

  FOLE was recently approved for use in PN-dependent patients in the United States. However, potential adverse effects of FOLE, including bleeding risk, and effects on the immune system [8], [39], render its use in certain patient populations controversial. Identification of key downstream modulators

• DNA repair is essential for

  2022-06-24

  

  DNA repair is essential for cell survival and for tissue homeostasis given that cellular DNA is constantly challenged by various endogenous and exogenous genotoxic factors that generate DNA damage: structural and chemical modifications of a primary DNA sequence. Various organisms have evolved multip

• Ionotropic glutamate receptors GluRs are ligand gated ion

  2022-06-24

  

  Ionotropic glutamate receptors (GluRs) are ligand-gated ion channels that mediate information processing at the majority of excitatory synapses in the brain and participate in such physiological processes as learning and memory, development and maintenance of cellular connections, and pain perceptio

• Analysis of genomic neighborhoods has

  2022-06-24

  

  Analysis of genomic neighborhoods has helped resolve questions concerning the orthology of receptors for peptides similar to glucagon (Ng et al., 2010, Irwin and Prentice, 2011, Wang et al., 2012, Hwang et al., 2013). Using a diverse array of species with available genome sequence (see Fig. 4) the g

14341 records 399/957 page Previous Next First page 上5页 396397398399400 下5页 Last page