• Involvement of Adiponectin in the

  2023-11-30

  

  Involvement of Adiponectin in the regulation of imatinib resistance in human CML cells has not been hitherto examined. Therefore, in this study, we first established imatinib-resistant K562 CML cells, and then evaluated the effect of Adiponectin in reversing imatinib resistance. The data presented h

• Given the profound expression of

  2023-11-30

  

  Given the profound CMX001 of 5-HT1A and 5-HT2A in the hippocampal CA1 region, and their potential to complex with mGluRs, the objective of this study was to examine if sleep deprivation alters the expression of 5-HT1A and 5-HT2A receptors and determine whether potential changes are reversible post

• As an alternative to chronic receptor blockade we have been

  2023-11-30

  

  As an alternative to chronic receptor blockade, we have been targeting adenosine kinase (ADK) – an astrocyte-based enzyme that catalyses the phosphorylation of adenosine, as a means to modify Pefloxacin mg adenosinergic signalling (Boison, 2006, Etherington et al., 2009). Up-regulating ADK facilita

• Synthesis pharmacological evaluation for the

  2023-11-30

  

  Synthesis, pharmacological evaluation for the binding at hA, hA and hA ARs, and efficacy at hA subtype of the synthesized compounds, together with the assessment of their theoretical ADME properties were the guidelines in this preliminary drug discovery investigation. The synthetic pathways which y

• The diagnosis of ICP is currently based on

  2023-11-30

  

  The diagnosis of ICP is currently based on the presence of pruritus, raised fasting serum TBS levels above 10μmol/L, and/or elevated serum transaminases (in the absence of diseases that cause cholestasis or pruritus) as well as spontaneous relief of signs and symptoms within four to six weeks after

• br Conflict of interest br Acknowledgments This

  2023-11-30

  

  Conflict of interest Acknowledgments This work was been partially supported by the following grants: C.I.S.I.A. project (Innovazione e Sviluppo del Mezzogiorno—Conoscenze Integrate per Sostenibilità ed Innovazione del Made in Italy Agroalimentare—Legge 191/2009) from the Italian Ministry of Ec

• br Aurora A Aurora B and Aurora C

  2023-11-30

  

  Aurora-A, Aurora-B and Aurora-C small molecule inhibitors Nicholas et al. described phenotypic cellular screening of new highly potent and selective class of Aurora kinase inhibitors. Fragment based approach was utilized; core structure of 57 (Fig. 5) was optimized and selective inhibitor 58 (Fi

• Structural and functional imaging studies

  2023-11-29

  

  Structural and functional imaging studies searching for specific cortical areas related to each cognitive function domain have provided clues to the spreading patterns of cognitive dysfunction (Domoto-Reilly et al., 2012, Firbank et al., 2016, Li et al., 2012, Machulda et al., 2003, Mandal et al., 2

• The rescue of the behavioral deficit was associated with a

  2023-11-29

  

  The rescue of the behavioral deficit was associated with a significant reduction in the levels of both soluble and insoluble Aβ peptides and their deposition in the p38 mapk inhibitor of the same animals. In search for the mechanism behind the reduced amyloidosis, we assessed APP metabolism. Confir

• br The lipoxygenase pathway in vascular physiology and patho

  2023-11-29

  

  The 12/15-lipoxygenase pathway in vascular physiology and pathology The mammalian 12- and 15-LOXs have high substrate specificity oxidizing predominantly ω−6 (arachidonic and linoleic acids) but also the ω−3 (docosahexanoic) doxercalciferol receptor [86], [87], [88]. Different LOXs oxidize fatty

• In this study we demonstrated that DRR protein level in

  2023-11-29

  

  In this study, we demonstrated that DRR1 protein level in GBM tissues was significantly higher compared to normal Ramipril tissues. This data suggested that DRR1 might play a role in the tumorigenesis of glioma. To investigate whether DRR1 could accurately predict the outcome in patients with gliom

• The purpose of this study is to

  2023-11-29

  

  The purpose of this BAPTA-AM mg study is to examine the relationship between ACEs and engagement in treatment among a sample of youth in residential treatment centers (RTCs). It is hypothesized that youth with higher ACE scores will have lower levels of engagement in treatment. In order to thorough

• br Funding br Introduction l Dihydroxyphenylalanine l DOPA i

  2023-11-29

  

  Funding Introduction l-3,4-Dihydroxyphenylalanine (l-DOPA) is the gold-standard treatment for the motor symptoms of Parkinson's disease (PD); however, its chronic use induces severe motor complications that eventually limit its long-term efficacy (Bastide et al., 2015). The most disabling side

• br LO and the secretase complex Supporting this concept duri

  2023-11-29

  

  5LO and the γ-secretase complex Supporting this concept, during a recent trial testing the γ-secretase inhibitor semagacestat (LY 450139), AD patients actually experienced a functional decline compared to patients who took a placebo in addition to several other significant adverse effects (Doody

• However for a molecular target

  2023-11-29

  

  However, for a molecular target to be useful in AD, it must rescue behavioral as well as biochemical insults. In humans, AD memory impairments typically declare themselves initially as disruption of episodic memory and consolidation of new memories, eventually progressing to global cognitive decline

14341 records 232/957 page Previous Next First page 上5页 231232233234235 下5页 Last page