Introduction Cardiovascular disease continues to be the lead

2019-08-28

Introduction Cardiovascular disease continues to be the leading cause of death in developed countries. Atherosclerosis, a chronic inflammatory cardiovascular disease, is characterized by the progressive buildup of oxidized low density lipoproteins in the arterial walls (Ross, 1999).

Besides having a remarkable progestogenic effect

2019-08-27

Besides having a remarkable progestogenic effect, an additional characteristic of DRSP is its strong antimineralocorticoid effect and antiandrogenic action [11].

As we all known hypoxia

2019-08-26

As we all known, hypoxia is a hallmark of tumour microenvironment, which is a key regulator of tumour growth and metastasis [4].

GRAIL family Gene related to anergy in

2019-08-24

GRAIL family Gene related to anergy in lymphocytes protein (GRAIL, encoded by Rnf128 gene) is a transmembrane RING-type E3 ligase involved in T cell anergy and tolerance, and also regulation of Ampalex cytoskeletal organization [52].

The two SNPs rs rs presented above are part

2019-08-23

The two SNPs rs4818-rs4680 presented above are part of the haploblock (rs6269, rs4633, rs4818, rs4680) presenting the 3 major haplotypes which influence the enzymatic activity of COMT.

Inflammatory action of certain cytokines

2019-08-22

Inflammatory action of certain cytokines can influence cell proliferative routes (Deshmane et al., 2009). When mTOR is inhibited, for instance by the action of Rapa, TGF-β1, which has an anti-inflammatory action, is increased.

Furthermore Survivin is a member of

2019-08-21

Furthermore, Survivin is a member of the inhibitor of apoptosis family. IR induces a rapid nuclear accumulation of survivin and subsequent phosphorylation of the protein in the nucleus.

Kumar et al studied Umbelliferone D galactopyranoside UFG be

2019-08-20

Kumar et al. studied Umbelliferone β-D-galactopyranoside (UFG) (benzopyrone), found in many plants exhibiting numerous pharmacological actions.

Y-27632 dihydrochloride Introduction Infection of cells by m

2019-08-19

Introduction Infection of Y-27632 dihydrochloride by microorganisms activates the inflammatory response. The initial sensing of infection is mediated by innate pattern recognition receptors (PRRs)including Toll-like receptors(TLRs) (Kawai and Akira, 2010; O’Neill et al., 2013).

Programmed cellular death or apoptosis is

2019-08-17

Programmed cellular death or apoptosis is a process genetically controlled that plays an important role in cellular homeostasis, being an important defense mechanism to remove cells that have been infected, damaged or mutated (Smith and Smith, 2012, Wlodkowic et al., 2011).

Methods Discussion and

2019-08-16

Methods Discussion and conclusions There were no statistically significant differences in pulmonary function outcomes (FEV1 and FVC) between the placebo and BAY 85-8501 treatment groups.

Programmed cell death via apoptosis is associated with a ser

2019-08-15

Programmed cell death via apoptosis is associated with a series of morphological and biochemical characteristics, including cell shrinkage, the rapid increase of intracellular calcium, nuclear condensation, DNA fragmentation and the formation of apoptotic bodies.

While oxysterols were most extensively studied for its

2019-08-14

While oxysterols were most extensively studied for its potent ability to mediate feedback regulation of cholesterol biosynthesis, some early investigations showed that the enzymes involved in its syntheses were highly upregulated in macrophages and dendritic cells—an indication of possible roles in immune related functions.,

Ubiquitination can occur on a

2019-08-13

Ubiquitination can occur on a single (monoubiquitination) or several (multiubiquitination) lysine residues, or the same lysine residue can be subjected to several rounds of Ub conjugation (polyubiquitination).

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2018-07-29