• EPAC induces SOCS gene expression in VECs resulting in

  2019-11-18

  

  EPAC1 induces SOCS3 gene expression in VECs, resulting in suppression of the JAK–STAT activation initiated by the sIL-6Rα/IL-6 trans-signalling complex [67]. EPAC1 regulates SOCS3 gene induction through the activation of C/EBP and c-Jun transcription factors, which interact directly with the SOCS3 p

• Host cell invasion by tachyzoites

  2019-11-18

  

  Host cell invasion by tachyzoites relies on the secretion of numerous secretory proteins and plays a crucial role in maintaining infection [6]. ESA released by tachyzoites are highly immunogenic and induce either antibody-dependent or cell-mediated protective immunity [11], [44], [45]. To investigat

• The N B method has

  2019-11-18

  

  The N&B method has the overall advantage that it is not restricted to certain dyes specific for energy transfer [55], and is also able to detect higher order receptor AZ20 on the focal point in living cells. Conclusion The N&B method has shown to be a powerful tool to locate and quantify the agg

• Prostaglandin E PGE is involved in several

  2019-11-18

  

  Prostaglandin E2 (PGE2) is involved in several biological processes such as renal function, inflammation, angiogenesis, and tumor growth. The various biological effects of PGE2 are mediated by the so-called E-type prostanoid receptors (EP1 to EP4). Among these, the EP4 receptor has been well studied

• The assembly and maturation of invadopodia can be initiated

  2019-11-18

  

  The assembly and maturation of invadopodia can be initiated by chemical stimuli such as the epidermal growth factor (EGF), as well as the mechanical signals from extracellular matrix (ECM). Upon binding, EGF activates the EGF receptor (EGFR), which further activates several intracellular signaling p

• DNA hypomethylation has been found in

  2019-11-18

  

  DNA hypomethylation has been found in liver tumor and other tumors of humans, such as laryngeal cancer, meclofenamate receptor tumors, tongue squamous cell carcinoma and uterine leiomyomas [[20], [21], [22], [23], [24]]. Then, we mainly sought to confirm whether TCA could induce DNA hypomethylation

• Other factors also contribute to replication fork progressio

  2019-11-18

  

  Other factors also contribute to replication fork progression in DNA damage conditions. For instance, the cullin Rtt101 has a role in fork movement through alkylated DNA, probably associated to a damage tolerance mechanism [52], and TORC signaling is also important for fork progression in response t

• Programmed cellular death or apoptosis is

  2019-11-16

  

  Programmed cellular death or apoptosis is a process genetically controlled that plays an important role in cellular homeostasis, being an important defense mechanism to remove cells that have been infected, damaged or mutated (Smith and Smith, 2012, Wlodkowic et al., 2011). Nevertheless, apoptosis s

• br Conflict of interest statement br Acknowledgement The

  2019-11-16

  

  Conflict of interest statement Acknowledgement The study was financially supported by the Ministry of Education, Youth and Sports of the Czech Republic – projects “CENAKVA” (No. CZ.1.05/2.1.00/01.0024) and “CENAKVA II” (No. LO1205 under the NPU I program), by the Grant Agency of the University

• A comparative analysis of the cleavage activity of different

  2019-11-16

  

  A comparative analysis of the cleavage activity of different forms of the BoNT/A endopeptidase in reduced conditions with SNAPtide and full-length SNAP-25 substrate is summarized in Fig. 5, Fig. 6. The BoNT/A LC was found to be the most active against SNAPtide, a small peptide segment of the SNAP-25

• Confirmation of the presence of H

  2019-11-16

  

  Confirmation of the presence of H+-PPase genes in the genomes of the different protists tested was obtained by Southern blot analyses using the PCR-amplified DNA fragments as probes (Fig. 3). In the trypanosomatids L. major and T. cruzi and the euglenoid A. longa, a single band appeared in the filte

• Calcium dependence of CaM target interaction was

  2019-11-16

  

  Calcium dependence of CaM/target interaction was analyzed using a titration matrix in which both Ca2+ and CaM concentrations were changed. This gave us access to different parameters characterizing the interaction and namely to the number of bound Ca2+ required for the interaction to occur. Our app

• It was recently reported that a functional single nucleotide

  2019-11-16

  

  It was recently reported that a functional single nucleotide polymorphism (rs75932628) within Triggering receptor expressed on myeloid integrin inhibitor 2 (TREM2) is associated with AD (Guerreiro et al., 2013). Homozygous loss of function mutations in TREM2 are also associated with an autosomal rec

• br Experimental br Results and discussion Fig shows

  2019-11-16

  

  Experimental Results and discussion Fig. 2 shows schematically the fundamentals of the developed HRP-P4-(P4)-anti-P4-Protein-G-MBs/SPCE immunosensor. Oriented immobilization of anti-P4 was accomplished onto Protein G-MBs due to the Protein G binding ability with the Fc region of many mammals i

• A similar pattern was observed for

  2019-11-16

  

  A similar pattern was observed for both tissues of P. harpagos, evidencing the absolute predominance of acetylcholinesterase. As observed, no effects were attributed to Iso-OMPA. The hypothesis that the major cholinesterasic form is AChE was reinforced considering the higher hydrolytic activity, whi

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