• Accessibility and physico chemical features of cysteine resi

  2021-09-07

  

  Accessibility and physico-chemical features of cysteine residues define their redox-reactivity and the 3-dimensional structure of GSNOR allows to identifying such surface-exposed, redox-sensitive cysteine residues. GSNOR crystal structures are available from human (Protein Data Bank code: 1MP0), tom

• Conflict of Interest The authors have no conflicts of intere

  2021-09-07

  

  Conflict of Interest: The authors have no conflicts of interest to declare. Acknowledgments Understanding Pulmonary Remodeling The effects of serotonin (5-hydroxytryptamine, 5-HT) class 2 receptors (5-HT2) on airway function and remodeling in respiratory disorders are unclear. Using murine pr

• br Lysophosphatidylinositol LPI LPI is

  2021-09-07

  

  Lysophosphatidylinositol (LPI) LPI is a subspecies of lysophospholipid consisting of inositol as its head group, one glycerol molecule and one acyl chain (Piñeiro and Falasca, 2012). The biosynthesis of this lipid starts from Phosphatidylinositol (PI) and is catalysed by the enzymes phospholipase

• br GPR is a class A GPCR expressed

  2021-09-07

  

  GPR119 is a class A GPCR expressed on pancreatic β-cells and certain enteroendocrine glut 1 which upon activation with an agonist, increases insulin secretion in response to rising glucose levels. Mechanistically, this insulinotropic effect is bifurcated involving both GPR119-mediated β-cell signa

• Four polymorphic variants of Neil

  2021-09-07

  

  Four polymorphic variants of Neil1, namely, S82C (rs5745905), G83D (rs5745906), C136R (rs5745907) and D252N (rs5745926) were characterized by Roy et al. in 2007 (Table 1). Analyses of AP site incision on Tg containing oligonucleotide showed that S82C and D252N variants had wild type activity and car

• No other lacZ mutant showed a marked difference in mutation

  2021-09-07

  

  No other lacZ mutant showed a marked difference in mutation rate between fpg and fpg backgrounds (that is, rates were comparable between HS101 and CSH1191, HS102 and CSH1192, etc.). The number of reversion mutants was much higher in HS1194 than in any other fpg strain. The inclusion of the pTRC99a p

• We next compared the enhancing effects

  2021-09-07

  

  We next compared the enhancing effects of 100nM zinc on currents produced by a low concentration of glycine with zinc effects on the same currents produced by the partial agonist taurine. In this experiment, zinc was co-applied with concentrations of glycine or taurine producing 5–10% of the maximal

• LbGlcK and the HsHxKIV d glucose complex PDB entry IDH

  2021-09-07

  

  LbGlcK and the HsHxKIV-d-glucose complex (PDB entry 3IDH) [17] were superimposed from individual subunits. The active site regions revealed the key Phosphoramidon Disodium Salt binding residues to be present for LbGlcK; also, the superposition showed that HsHxKIV had residues that were absent in Lb

• br Results and Discussion br STAR Methods br

  2021-09-07

  

  Results and Discussion STAR★Methods Author Contributions Conflicts of Interest J.P.F. is a consultant for AstraZeneca, BMS, Johnson and Johnson, Novo Nordisk, and Sanofi, a member of the advisory panel for AstraZeneca and Sanofi, a member of the speaker’s bureau for Sanofi and Novo Nordi

• br Disclosure br Ghrelin System

  2021-09-07

  

  Disclosure Ghrelin System The existence of the ghrelin system has been demonstrated in many species through a variety of biochemical, anatomical, and genetic studies. It is a complex and intricate regulatory system comprised of several peptides, including mature ghrelin and its derivative des-

• After the successful development of

  2021-09-06

  

  After the successful development of molecular targeted drugs in lung adenocarcinoma, substantial efforts have been made to provide similar targeted drugs in lung squamous-cell carcinoma. Because FGFR gene alteration is the most frequent occurrence in squamous-cell carcinoma, targeted therapies for F

• br Materials and methods br Results and discussion

  2021-09-06

  

  Materials and methods Results and discussion Conclusion The as-designed system was based on the assembly of MSN-Cy and TPGS, which was dominated by π-π stacking interactions. By the strong mutual force, Cypate and TPGS formed a compact layer around the MSN core, which blocked the drug leaka

• matrix metalloproteinase br Role of catecholamines in HIV as

  2021-09-06

  

  Role of catecholamines in HIV-associated neuroinflammation Concluding remarks However, more research is needed to determine the precise mechanisms responsible for the immunomodulatory effects of catecholamines, including the involvement of specific receptors and signaling pathways in immune ce

• The proposed contributory role of endogenous histamine via a

  2021-09-06

  

  The proposed contributory role of endogenous histamine via activation of H1 receptor in the locomotor sensitization induced by caffeine was further ratified by H1 receptor antagonism during the induction phase and subsequently its effect on expression to locomotor sensitization induced by caffeine.

• The isoenzyme hGSTP is an attractive drug target due to

  2021-09-06

  

  The isoenzyme hGSTP1-1 is an attractive drug target due to its high levels of disease association (target validation) and druggability (target tractability) properties [5,6,[17], [18], [19], [20], [21]]. hGSTP1-1 functions as a homodimer protein [18]. Each monomer has two domains, an α/β domain (N-t

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