• Upregulation of ACLY is common

  2023-01-05

  

  Upregulation of ACLY is common in many cancers (Kuhajda, 2000, Milgraum et al., 1997, Swinnen et al., 2004, Yahagi et al., 2005). This is in part due to the transcriptional activation by SREBP-1 resulting from the activation of the PI3K/AKT pathway in cancers (Kim et al., 2010, Nadler et al., 2001,

• br Experimental br Results and discussion br Conclusion br A

  2023-01-05

  

  Experimental Results and discussion Conclusion Acknowledgments This work is supported by the National Basic Research Program of China (973 Program 2016YFA0201201 and 2013CB932702), a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAP

• The physiologic conditions and signaling mechanisms that reg

  2023-01-05

  

  The physiologic conditions and signaling mechanisms that regulate apelin secretion and APLNR expression in malignant tissues appear to be multifactorial. Previous studies have shown that hyperplastic and neoplastic cholangiocytes secrete a variety of hormones, peptides, and growth factors that help

• br Material and methods br Results br Discussion

  2023-01-05

  

  Material and methods Results Discussion Didox was originally created asa cytostatic drug to inhibit cancer cell proliferation by antagonizing RNR [11]. When used to target highly proliferative cells, Didox has extensive activity in vitro and in vivo. It has also been employed in clinical st

• br Conclusion br Introduction Breast cancer

  2023-01-05

  

  Conclusion Introduction Breast cancer is the most common cancer and second leading cause of cancer-related deaths in women [1,2]. There were about 1.7 million new cases of breast cancer worldwide in 2012 [3], and the number of new cases of female breast cancer is expected to increase to 3.2 mi

• Plant tissues were thought to be natural sources containing

  2023-01-05

  

  Plant tissues were thought to be natural sources containing different types of antioxidant compounds (tocopherols, ascorbic acid, carotenoids, and phenolic compounds). As a general classification, antioxidants were grouped as vitamins (ascorbic acid, tocopherols), carotenoids (condensed tannins, xan

• Platelet derived growth factor PDGF and

  2023-01-05

  

  Platelet-derived growth factor (PDGF) and ciliary neurotrophic factor (CNTF) are expressed by glial Pentamidine dihydrochloride and are important to neuron survival and the maintenance of oligodendrocytes. These neurotrophic factors contribute to the remyelination process by increasing the prolifera

• Solamargine br Author Contributions br Acknowledgments

  2023-01-05

  

  Author Contributions Acknowledgments Introduction Cerebral ischemia-reperfusion (I/R) injury is a pathological phenomenon that occurs after restoration of blood supply to Solamargine tissues subsequent to ischemia or hypoxia (Carden and Granger, 2000). It typically occurs after therapeutic

• A number of interesting anti inflammatory molecules

  2023-01-05

  

  A number of interesting anti-inflammatory molecules have also been identified that are derived from AA or ω−3 fatty acids, including the lipoxins (for “lipoxygenase interaction products”), resolvins, and protectins [18], [19] (Fig. 1). The lipoxins are synthesized from AA by 5-, 12-, and 15-LOX, as

• The current study was designed to

  2023-01-05

  

  The current study was designed to investigate the effects of the 12/15-LOX inhibitor, LOXBlock-1 (LB1) in mice using a FeCl3-induced distal MCAO model, and to test its utility in conjunction with subsequent thrombolysis with tPA, which is to date the only FDA-approved drug for acute stroke treatment

• br Introduction Alzheimer s disease

  2023-01-05

  

  Introduction Alzheimer's disease (AD) is a neurodegenerative disorder and the leading cause of dementia. It is characterized by progressive and irreversible damage to different monensin mg areas, resulting in cognitive impairment and behavioral changes (O'Neill, 2013, De Strooper and Karran, 201

• Furthermore our lab previously reported that cadmium treatme

  2023-01-04

  

  Furthermore, our lab previously reported that cadmium treatment increased AChE-S and decreased AChE-R variants gene expression, which mediates the cell death observed on basal forebrain cholinergic neurons (Del Pino et al., 2016b). AChE-R decreased expression, which presents a neuroprotective role i

• In this study in an effort to

  2023-01-04

  

  In this study, in an effort to explore the possible role of 5-HT6 receptors in mediating the memory-enhancing effects of YL-0919, we first assessed the memory-enhancing effects of YL-0919 in the Morris water maze, object recognition test and step-down passive avoidance task. In addition, we then inv

• Free Fatty Acid Quantification Colorimetric/Fluorometric Kit

  2023-01-04

  

  Material and methods Results Discussion Clinical gene therapy trials with viral vectors have been in use for treatment of various genetic disorders and diseases, however efficacious, targetable and highly reliable non-viral delivery systems are needed for safe and long-term applications. De

• br Conclusion br List of abbreviations br Acknowledgment The

  2023-01-04

  

  Conclusion List of abbreviations Acknowledgment The studies performed by our laboratory and presented in this review were supported by the Ministry of Education, Culture, Sports, Science and Technology of Japan, (KAKENHI 17590618 [to H.I.] and KAKENHI 22249017 [to Y.Y.]), and the Japanese S

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